Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

chemical composition of essential oil of ferulago macrocarpa (fenzl) boiss. fruits

water-distilled essential oil of ferulago macrocarpa (umbelliferae) fruits was analyzed using gc-ms for the first time. forty-two components comprising 99.5% of the total oil were identified, of which bornyl acetate (40.8%), 2,3,6-trimethyl benzaldehyde (7.2%), δ-selinene (5.5%), 1,10-di-epi-cubenol (5.1%), germacrene d (3.5%), β-phellandrene (3.5%) and α-pinene (3.4%) were found to be the majo...

ferulagoa macrocarpa (fenzl) boiss. fruits as a source of bornyl acetate and 1,10-di-epi-cubenol

Effects of dihydropyrano coumarins from Ferulago macrocarpa on VEGF, MMP9, MMP2 and study of binding modes using computational methods

Background and objectives: Ferulago macrocarpa of Apiaceae (Umbelliferae) is native to the highlands of the west of Iran which contains dihydrocoumarins from phenolic class. Studies have shown that phenolic compounds at physiological concentrations could inhibit two groups of gelatinase matrix metalloproteinases (MMP2, MMP9). Due to the high diversity of coumarins in t...

In vitro study of the effects of dihydropyrano coumarins isolated from Ferulago macrocarpa on DNA by spectroscopic and molecular modeling methods

Background and objectives: Coumarins have potential anticancer effects. Ferulago macrocarpa (Fenzl) Boiss, is a perennial herb which has shown to have several dihydropyranocoumarins like grandivittin (GRA) and dihydrofuranocoumarins such as prantschimgin (PRA). Previously the antibacterial, cytotoxic and antioxidant effect of GRA and PRA have been reported. Understandi...

Phytochemicals, Phenolic Profiles, Antioxidant and Antibacterial Activities of Ferulago macrocarpa Extracts from Lorestan

Ferulago macrocarpa (Fenzl) Boiss. commonly known as Chavil e Roshanball in Persian is a medicinal and aromatic plant from the Apiaceae family that grows in the west of Iran. The aim of this study was to investigate the phytochemical components, phenolic contents, antioxidant and antibacterial activities of hydroalcoholic extracts of F. macrocarpa flower and leaf from Lorestan...